Life-sciences/ Pharmaceutical Sciences/ Pharmacy & Drugs
Natural Products - Drug Développement
Description
Le impor¬tance de natural products pour medicine et health has been enormous. Due to diverse biological activities et medicinal potentials de natural products, nearly every civilization has accumulated experience et knowledge de their use. During le last two decades, research aimed at exploiting natural products as a resource has seriously declined. This is en part due to le development de new technologies such as combinatorial chemistry, metagenomics et high-throughput screening. However, le new drug discovery approaches did not fulfilled le initial expectations. This has lead to a renewed interest en natural products, determined by le urgent need pour new drugs, en particular to fight against infections caused by multi-resistant pathogens. Besides, untapped biological resources, “smart screening” methods, robotic separation avec structural analysis, metabolic engineering, et synthetic biology offer exciting technologies pour new natural product drug discovery. However, one de le greatest challenges is to identify natural compounds or naturally inspired compounds that can be combined to be effective against human diseases. Thus, le mod¬ern pharmaceutical researches today use powerful tools de genomics, proteomics, metabolomics, synthetic et combinatorial chemistry pour development de new candidature drug. Le book “NATURAL PRODUCTS-DRUG DEVELOPMENT” provides le reader avec recent information sur drug discovery from natural sources et its development using mod¬ern pharmaceutical research tools. Le contributors are eminent subject experts working en le field de product development from natural sources such as plants, animals or microorganisms. Le most remarkable feature de this book is le biotechnological et pharmaceutical approaches et structure elucidation de active molecules. This book would cater le need de graduate et post graduate students pursuing their study en all branches de life-sciences, pharmaceutical sciences, researchers et scientists working en le laboratories et industries involved en natural product discovery
Table des matières
Forward, Preface, List de contributors; Section I: MICROBIAL DRUG DISCOVERY: Bioprospecting Soil Microorganisms pour Novel Bioactive Metabolites, Microalgae: Un Potential Source de Bioactive Metabolites, Diversity de Wild Mushrooms et its Medicinal Uses, Endolichenic Fungi as a Source de Novel Bioactive Metabolites: Present et Future Prospects, Endophytic Fungi de Medicinal Plantees as a Source de Novel Bioactive Compounds; Section II: BIOACTIVE METABOLITES FROM PLANTS THROUGH IN VITRO CULTURES: Changing Socio-Cultural Perspectives sur le Use de Phytotherapeutics, Screening de Antibacterial Potential de Medicinal Plantees, Biotechnologie et Herbal Medicine, Plante Cell Culture – Un Efficient Source de Secondary Metabolites, Root Culture pour Secondary Metabolites Production, Micro RNAs as Therapeutic Molecules pour le Effective Treatment de Diseases, Transgenic Plantees en Biopharming; Section III: DEVELOPMENT OF PHARMACEUTICAL DRUGS: Natural Products en Drug Discovery et Développement: Un Overview, Ordinateur Aided Drug Conception, Retrosynthesis en le Chimie de Natural Products-I, Retro Synthesis en le Chimie de Natural Products-II, Structural Elucidation de Small Molecules: IR- 1H NMR-13CNMR – Mass Spectra, Subject Index.